TP53 mutation status: emerging biomarker for precision radiation medicine?

PIK3CA mutation and colorectal cancer precision medicine

The pathogenesis of colorectal adenocarcinoma is driven by the accumulation of multiple genetic and epigenetic aberrations, and is influenced by various endogenous and exogenous factors [1] [Kudryavtseva AV, et al. Oncotarget. 2016;7:53959-53983]. Phosphatidylinositol-4,5-bisphosphonate 3-kinase (PI3K) serves as a major signaling hub downstream of epidermal growth factor receptor (EGFR). The PI...

An Emerging Role for Radiation Oncology in Precision Oncology

Article history: Received 1 March 2016 Accepted 1 March 2016 Available online 4 March 2016 the precision of radiotherapy delivery (e.g. computational algorithms, IMRT, IGRT, SBRT); and3. Incorporationof novel radiosensitizing andmolecular targeting agents with radiation therapy to reduce mechanisms of radiation resistance (e.g. epithelial growth factor receptor inhibitors and RT in head and nec...

Metabolomics: an emerging but powerful tool for precision medicine

Metabolomics, which is defined as the comprehensive analysis of metabolites in a biological specimen, is an emerging technology that holds promise to inform the practice of precision medicine. Historically, small numbers of metabolites have been used to diagnose complex metabolic diseases as well as monogenic disorders such as inborn errors of metabolism. Current metabolomic technologies go wel...

Specific TP53 mutation pattern in radiation-induced sarcomas.

The mutagenic properties of ionizing radiation are well known, but the presence of specific mutations in human radiation-induced tumours is not established. We have studied a series of 36 secondary sarcomas arising in the irradiation field of a primary tumour following radiotherapy. The allelic status and the presence of mutations of the TP53 gene were investigated. The mutation pattern was com...

precision medicine for endocrinology